Microbial transformation of 6-O-methylerythromycin derivatives.
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چکیده
منابع مشابه
14-Hydroxy-6-O-methylerythromycins A, active metabolites of 6-O-methylerythromycin A in human.
(14R)-14-Hydroxy-6-O-methylerythromycin A and (14S)-epimer have been isolated as active metabolites from human urine after oral administration of 6-O-methylerythromycin A (TE-031, A-56268). The structures of these metabolites were determined by means of mass, 1H and 13C NMR spectroscopies. Antimicrobial activities of (14R)-14-hydroxy-6-O-methylerythromycin A, a major metabolite, were comparable...
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6-O-Methylerythromycin B has been synthesized from erythromycin B via regioselective methylation of the 6-hydroxyl group in 71% overall yield. This compound shows in vitro antibacterial activity comparable to erythromycins A and B and exhibits superior in vivo activity with improved pharmacokinetic properties.
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(-)-Alloisolongifolene (1) is a structural analogue of the naturally occurring longifolene. The microbial transformation of (-)-alloisolongifolene (1) by Cunninghamella elegans afforded two new metabolites, 3a-hydroxyalloisolongifolol (2) and 13-hydroxyalloisolongifolol (3). The structures of the metabolites were deduced on the basis of their spectral data, including 1D and 2D NMR, IR and HREIMS.
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1988
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.41.908